Technology OverviewSelected Publications

Technology Selected Publications     Targeted drug delivery with dendrimers: Comparison of the release kinetics of covalently conjugated drug and non-covalent drug inclusion complex Patri AK, Kukowska-Latallo JF, Baker JR Jr. Advanced Drug Delivery Reviews 2005, 57(15):2203-14 Tumor angiogenic vasculature targeting with PAMAM dendrimer–RGD conjugates Shukla R, Thomas TP, Peters J, Kotlyar A, Myc A, Baker Jr JR. Chemical Communications 2005, (46):5739-41 Prevention of Influenza Pneumonitis by Sialic Acid–Conjugated Dendritic Polymers Landers JJ, Cao Z, Lee I, Piehler LT, Myc PP, Myc A, Hamouda T, Galecki AT, Baker JR Jr. The Journal of Infectious Diseases 2005, 186(9):1222-30 Silver/Dendrimer Nanocomposites as Biomarkers: Fabrication, Characterization, in vitro Toxicity, and Intracellular Detection Lesniak W, Bielinska AU, Sun K, Janczak KW, Shi X, Baker JR Jr, Balogh LP. Nano Letters 2005, 5(11):2123-30 Poly(amidoamine) Dendrimer-Based Multifunctional Engineered Nanodevice for Cancer Therapy Majoros IJ, Thomas TP, Mehta CB, Baker JR Jr. Journal of Medicinal Chemistry 2005, 48(19):5892-9 HPLC analysis of PAMAM dendrimer based multifunctional devices Islam MT, Majoros IJ, Baker JR Jr. Journal of Chromatography B 2005, 822(1-2):21-6 Analysis of poly(amidoamine)-succinamic acid dendrimers by slab-gel electrophoresis and capillary zone electrophoresis Shi X, Patri AK, Lesniak W, Islam MT, Zhang C, Baker JR Jr, Balogh LP. Electrophoresis 2005, 26(15):2960-7 Capillary electrophoresis of polycationic poly(amidoamine) dendrimers Shi X, Banyai I, Lesniak WG, Islam MT, Orszagh I, Balogh P, Baker JR Jr, Balogh LP. Electrophoresis 2005, 26(15):2949-59 Nanoparticle Targeting of Anticancer Drug Improves Therapeutic Response in Animal Model of Human Epithelial Cancer Kukowska-Latallo JF, Candido KA, Cao Z, Nigavekar SS, Majoros IJ, Thomas TP, Balogh LP, Khan MK, Baker JR Jr. American Association for Cancer Research 2005, 65(12):5317-24 Capillary Electrophoresis of Poly(amidoamine) Dendrimers: From Simple Derivatives to Complex Multifunctional Medical Nanodevices Shi X, Majoros IJ, Baker JR Jr. Molecular Pharmaceutics 2005, 2(4):278-94 Targeting and Inhibition of Cell Growth by an Engineered Dendritic Nanodevice Thomas TP, Majoros IJ, Kotlyar A, Kukowska-Latallo JF, Bielinska A, Myc A, Baker JR Jr. Journal of Medicinal Chemistry 2005, 48(11):3729-35 HPLC Separation of Different Generations of Poly(amidoamine) Dendrimers Modified with Various Terminal Groups Islam MT, Shi X, Balogh L, Baker JR Jr. Analytical Chemistry 2005, 77(7):2063-70 Synthesis and Functional Evaluation of DNA-Assembled Polyamidoamine Dendrimer Clusters for Cancer Cell-Specific Targeting Choi Y, Thomas T, Kotlyar A, Islam MT, Baker JR Jr. Chemistry & Biology 2005, 12(1):35-43 Synthesis and in vitro Testing of J591 Antibody-Dendrimer Conjugates for Targeted Prostate Cancer Therapy Patri AK, Myc A, Beals J, Thomas TP, Bander NH, Baker JR Jr. Bioconjugate Chemistry 2004, 15(6):1174-81 In vitro Targeting of Synthesized Antibody-Conjugated Dendrimer Nanoparticles Thomas TP, Patri AK, Myc A, Myaing MT, Ye JY, Norris TB, Baker JR Jr. Biomacromolecules 2004, 5(6):2269-7 Detection and Analysis of Tumor Fluorescence Using a Two-Photon Optical Fiber Probe Thomas TP, Myaing MT, Ye JY, Candido K, Kotlyar A, Beals J, Cao P, Keszler B, Patri AK, Norris TB, Baker JR Jr. Biophysical Journal 2004, 86(6):3959-65 Deformability of poly(amidoamine) dendrimers Mecke A, Lee I, Baker JR Jr, Holl MM, Orr BG. The European Physical Journal E 2004, 14(1):7-16 Ligand-targeted therapeutics in anticancer therapy Allen TM. Nature Reviews 2002, 2(10):750-63 Design and Function of a Dendrimer-Based Therapeutic Nanodevice Targeted to Tumor Cells Through the Folate Receptor Quintana A, Raczka E, Piehler L, Lee I, Myc A, Majoros I, Patri AK, Thomas T, Mule J, Baker JR Jr. Pharmaceutical Research 2002, 19(9):1310-6 Dendritic polymer macromolecular carriers for drug delivery Patri AK, Majoros IJ, Baker JR. Current Opinion in Chemical Biology 2002, 6(4):466-71 Combination of Electroporation and DNA/Dendrimer Complexes Enhances Gene Transfer into Murine Cardiac Transplants Wang Y, Bai Y, Price C, Boros P, Qin L, Bielinska AU, Kukowska-Latallo JF, Baker JR Jr, Bromberg JS American Journal of Transplantation 2001, 1(4):334-8 DNA/Dendrimer Complexes Mediate Gene Transfer into Murine Cardiac Transplants ex vivo Wang Y, Boros P, Liu J, Qin L, Bai Y, Bielinska AU, Kukowska-Latallo JF, Baker JR Jr, Bromberg JS. Molecular Therapy 2000, 2(6):602-8 Intravascular and Endobronchial DNA Delivery to Murine Lung Tissue Using a Novel, Nonviral Vector Kukowska-Latallo JF, Raczka E, Quintana A, Chen C, Rymaszewski M, Baker JR Jr. Human Gene Therapy 2000, 11(10):1385-95 The use of PAMAM dendrimers in the efficient transfer of genetic material into cells Eichman JD, Bielinska AU, Kukowska-Latallo JF, Baker JR Jr. Pharmaceutical Science & Technology Today 2000, 3(7):232-245 Application of membrane-based dendrimer/DNA complexes for solid phase transfection in vitro and in vivo Bielinska AU, Yen A, Wu HL, Zahos KM, Sun R, Weiner ND, Baker JR Jr, Roessler BJ. Biomaterials 2000, 21(9):877-87 Enhancement of Dendrimer-Mediated Transfection Using Synthetic Lung Surfactant Exosurf Neonatal in vitro Kukowska-Latallo JF, Chen C, Eichman J, Bielinska AU, Baker JR Jr. Biochemical and Biophysical Research Communications 1999, 264(1):253-61 DNA Complexing with Polyamidoamine Dendrimers: Implications for Transfection Bielinska AU, Chen C, Johnson J, Baker JR Jr. Bioconjugate Chemistry 1999, 10(5):843-50 Inhibition of Viral Adhesion and Infection by Sialic-Acid-Conjugated Dendritic Polymers Reuter JD, Myc A, Hayes MM, Gan Z, Roy R, Qin D, Yin R, Piehler LT, Esfand R, Tomalia DA, Baker JR Jr. Bioconjugate Chemistry 1999, 10(2):271-8 The effect of synthetic surfactant Exosurf on gene transfer in mouse lung in vivo Raczka E, Kukowska-Latallo JF, Rymaszewski M, Chen C, Baker JR Jr. Gene Therapy 1998, 5(10):1333-9 Regulation of in vitro gene expression using antisense oligonucleotides or antisense expression plasmids transfected using starburst PAMAM dendrimers Bielinska A, Kukowska-Latallo JF, Johnson J, Tomalia DA, Baker JR Jr. Nucleic Acids Research 1996, 24(11):2176-82 Efficient transfer of genetic material into mammalian cells using Starburst polyamidoamine dendrimers Kukowska-Latallo JF, Bielinska AU, Johnson J, Spindler R, Tomalia DA, Baker JR Jr. Proceedings of the National Academy of Sciences of the United States of America 1996, 93(10):4897-902